CAV1 and infection: The P.1.2 sublineage carries some different mutations in comparison to the P.1 lineage and it was considered a Variant of Interest (VOI) due to the mutation D155Y in the ORF3a, which results in a low viral affinity to the host caveolin-1 protein, thereby avoiding cell apoptosis and extending the asymptomatic phase of infection (11, 16).