MAVS and viral infectious disease: We also analyzed the overlap of proteomic hits with annotated UniProt keywords of “antiviral defense” and “innate immunity” and found a slight enrichment of these proteins in cluster 8 that tend to be degraded by viral infection, including cytosolic sensors like MAVS, DHX36, and DDX3 and antiviral restriction factors like TRIM25, TRIM38, and so on (Fig. S4B).