We also analyzed the overlap of proteomic hits with annotated UniProt keywords of “antiviral defense” and “innate immunity” and found a slight enrichment of these proteins in cluster 8 that tend to be degraded by viral infection, including cytosolic sensors like MAVS, DHX36, and DDX3 and antiviral restriction factors like TRIM25, TRIM38, and so on (Fig. S4B). The gene discussed is TRIM25; the disease is viral infectious disease.