Patients with homozygous loss‐of‐function variants in the OTU‐deubiquitinase OTULIN suffer from neonatal‐onset OTULIN‐related autoinflammatory syndrome (ORAS) characterized by fever, panniculitis, diarrhea, and arthritis. This evidence concerns the gene OTULIN and autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.