Moreover, two independent groups identified a surplus of linear ubiquitin linkages in humans due to homozygous variants in OTULIN to result in an autoinflammatory disease: OTULIN‐Related Autoinflammatory Syndrome (ORAS) or Otulipenia (Damgaard et al, 2016; Zhou et al, 2016). Here, OTULIN is linked to autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.