The fourth cluster includes keywords related toassociation, and the main keywords are risk factors, smoking, ocular surface, dryeye, tear film osmolarity, children, glaucoma, intraocular pressure, Graves’disease, auto-antibodies, thyrotropin receptor antibody, prevalence, and population.We can find the main risk factors for TED in this keyword cluster, includingsmoking, radioiodine therapy, and hyperthyroidism(20). The gene discussed is TSHR; the disease is glaucoma.