It is mostly concerned with Hepatitis B, cancer pathways, the IL pathway, the AP1 signaling pathway, the HIF-1 signaling system, the VEGFR1 pathway, prion disorders, endocrine resistance, the Myc pathway, the SMAD2 pathway, the SHP2 pathway, the FRA pathway, and so on. The gene discussed is FOS; the disease is hepatitis B virus infection.