It is mostly concerned with Hepatitis B, cancer pathways, the IL pathway, the AP1 signaling pathway, the HIF-1 signaling system, the VEGFR1 pathway, prion disorders, endocrine resistance, the Myc pathway, the SMAD2 pathway, the SHP2 pathway, the FRA pathway, and so on. This evidence concerns the gene SMAD2 and hepatitis B virus infection.