To first explore the expression pattern of DIRAS3 in NSCLC, we first searched the StarBase database (http://starbase.sysu.edu.cn/panGeneDiffExp.php) and the GEPIA database (http://gepia.cancer-pku.cn/detail.php?gene=DIRAS3&clicktag=boxplot) and found that DIRAS3 was poorly expressed in lung adenocarcinoma and lung squamous cell carcinoma (Figure 1(a,b)). This evidence concerns the gene DIRAS3 and squamous cell lung carcinoma.