NFKB1 and colorectal carcinoma: F. nucleatum levels are elevated in CRC tissues compared to normal controls and the enriched abundance is associated with poor prognosis and shortened survival.[8] Additional studies have demonstrated that F. nucleatum promotes colorectal carcinogenesis and progression by manipulating the immune microenvironment, recruiting tumor‐infiltrating lymphocytes, protecting CRC cells from immune cell attack, inducing resistance to chemotherapy, and activating signaling pathways such as NF‐κB.[8, 9] However, the potential regulation of F. nucleatum on CCSCs has not been investigated.