In fact, CPT1B has been reported to be regulated by NF‐κB through SUMO specific protease 2 (SENP‐2), while FASN is regulated by sterol regulatory element binding proteins (SREBPs), which are targets of NF‐κB.[24, 30] To this end, NF‐κB regulates different metabolic genes in CCSCs and regular CRC cells, thereby mediating distinct lipid metabolisms. This evidence concerns the gene SENP2 and colorectal carcinoma.