Some evidence shows that F. nucleatum activates NF‐κB in CRC cells, while activated NF‐κB has been reported to upregulate CPT1B.[24] Thus, we hypothesized that F. nucleatum elevated CPT1B expression, likely through activation of NF‐κB. Consistent with previous reports, we observed that F. nucleatum infection indeed activated NF‐κB in CRC cells as well as CCSCs through the TLR4/MyD88 axis (Figure S6A, Supporting Information). This evidence concerns the gene NFKB1 and colorectal carcinoma.