In this study, we determined the levels of vasorin in the AH of POAG patients, expression, secretion and release of the soluble form of vasorin by HTM cells, effects of vasorin on TGF‐β2 mediated cellular events and in TNF‐α induced TM cell death, to gain insights into the role of this glycoprotein in TM biology, AH dynamics and IOP. The gene discussed is VASN; the disease is open-angle glaucoma.