Importantly, elevated levels of TGF‐β is not only a common finding in the AH of POAG patients, but increased levels of TGF‐β are recognized to elevate IOP by stimulating fibrogenic activity and transdifferentiation of TM cells into extracellular matrix producing fibroblast‐like cells.11, 27, 35. The gene discussed is TGFB1; the disease is open-angle glaucoma.