Alterations in levels of various external factors including TGF‐β, endothelin‐1, connective tissue growth factor (CTGF), lysophosphatidic acid (LPA), TNF‐α, autotaxin and extracellular matrix in the AH of glaucoma patients have been found to be associated with elevated IOP in glaucoma patients.6, 7, 8, 9, 10, 11, 12, 13. This evidence concerns the gene CCN2 and glaucoma.