Since elevated levels of TGF‐β, EndMT (endothelial‐to‐mesenchymal transition) and fibrogenic activities are presumed to play a part in ocular hypertension and glaucoma,33, 35, 36 we determined the effects of vasorin on TGF‐β2 mediated activation of SMAD2/3, and expression of α‐SMA and fibronectin in TM cells. The gene discussed is SMAD2; the disease is ocular hypertension.