Alterations in levels of various external factors including TGF‐β, endothelin‐1, connective tissue growth factor (CTGF), lysophosphatidic acid (LPA), TNF‐α, autotaxin and extracellular matrix in the AH of glaucoma patients have been found to be associated with elevated IOP in glaucoma patients.6, 7, 8, 9, 10, 11, 12, 13. The gene discussed is TNF; the disease is glaucoma.