Vasorin was found to exhibit anti‐TGF‐β and anti‐apoptotic activity in TM cells implying that dysregulation of production and/or secretion of this key glycoprotein by TM cells may be contributory to the pathobiology of ocular hypertension and glaucoma and that vasorin may therefore be a therapeutic target in glaucoma. The gene discussed is VASN; the disease is ocular hypertension.