In principle, obesity could contribute in multiple ways to the evolution of infection: (a) down-modulating the antiviral responses [6]; (b) releasing lipids that promote endothelial dysfunction and sustain intravascular coagulation [7]; (c) disrupting leptin and insulin signaling, thus intensifying the inflammatory response [8]; (d) promoting enhanced expression of SARS-CoV-2 receptors [9]; (e) representing a large reservoir for virus replication with increased shedding of virus and inflammatory mediators [10]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.