In pediatric CNS neoplasms these 72 kinase fusions appear as 118 unique fusion–entity pairs, mainly in glial entities (97%; 114/118), except for some NTRK- (2%; 2/118), ALK- (1%; 1/118) and ROS1- (1%; 1/118) fusions that have been identified in non-glial tumors (Fig. 3a) [133, 145, 190]. Here, ROS1 is linked to central nervous system neoplasm.