Gibbs et al. confirm that reduction in REVERBα increased IL-6 and other cytokines in human and mouse macrophages, whilst another group demonstrated that SR9009 (Reverbα agonist) improves survival in a murine caecal ligation puncture model of sepsis [36], suggesting through mixed REVERBα and light studies that this was a pathway through which blue light improves survival in their model of Klebsiella pneumonia in mice. Here, NR1D1 is linked to Klebsiella pneumonia.