CSF1 and Hepatic fibrosis: However, some of the earliest studies of CSF1 in disease models also showed the potential for exacerbation of inflammatory pathology (Hume and MacDonald, 2012), and macrophage depletion with anti-CSF1R or anti-CSF1 was previously shown to ameliorate development of toxin-induced liver fibrosis in mice (Mehal et al., 2001; Seifert et al., 2015).