SARS-CoV-2 infection, the causative agent of COVID-19, elicits a broad range of symptoms: fever, cough, shortness of breath, and myalgia are the most reported symptoms among critically ill patients.1 Antibody levels serve as a potential correlate of protection against COVID-19; individuals who test positive for anti-spike and anti-nucleocapsid IgG antibodies have demonstrated a substantially reduced risk of SARS-CoV-2 reinfection.2 Moreover, high vaccine-induced antibody responses are associated with lower risk of symptomatic COVID-19.3 Here, CHMP5 is linked to COVID-19.