NR3C1 and post-traumatic stress disorder: NR3C1is another most studied gene which encodes the GR.NR3C1plays a key role in the understanding of the epigenetic regulation of PTSD and fear extinction processes.65As a result of the study examining the relationship between the methylation level of theNR3C1promoter and PTSD, it is emphasized that the higher level of DNA methylation in the NR3C1 promoter region could be a protective effect against vulnerability to PTSD.66