Methylation studies showed that FK506 binding protein 51 gene,BRSK1,LCN8,NFG,DOCK2,ZFP57,RNF39,46, 47, 48BDNF,NR3C1,MAN2C1,TLR8,SLC6A4,IL-18,SKA2,3LINC01090, BC036345, ZNRD1-ASI, andRORA,49, 50, 51, 52, 53, 54, 55TPR,ANXA2,CLEC9A,ACP5,TLR8,LRRC3B,BRSK1,LCN8,NGF,DOCK2,48DUSP22,HIST1H2APS2,HOOK2,NINJ2,PAX8,RNF39,ZFP57,56NRG1,HGSgenes are related with PTSD and severity of symptoms48, 56, 57(Table 1). The gene discussed is RNF39; the disease is post-traumatic stress disorder.