TLR8 and post-traumatic stress disorder: HDAC4gene was related to learning and memory-related processes and studies demonstrated that higher level methylation was observed in PTSD cases.63In the study whereBDNF,NR3C1,MAN2C1,TLR8,SLC6A4,IL-18, andSKA2gene methylation analyses were performed in patients suffering from PTSD, it was concluded that BDNF, NR3C1 and MAN2C1 methylations are associated with PTSD diagnosis.3This study revealed the importance the regulation of genes involved in synaptic plasticity and the HPA axis and their association with PTSD.