A PRS constructed from a clumping and P-value threshold approach PRS(C + T) and related methods outperform or are comparable with other approaches (e.g. LDPRED and SBayesR).13 The best prediction was observed in a model combining directly measured APOE with the PRS excluding the APOE region at a threshold of P ≤ 0.10, whereas the prediction accuracy was attenuated at more relaxed thresholds despite increases in variants.13 Altogether, recent findings suggest that Alzheimer’s disease is polygenic and the age-related nature of the risk is essential to consider.13 This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.