APOE and early-onset autosomal dominant Alzheimer disease: In Reduced Model 1, AP for the full PRS accounted for 10.1% (σ2Aᴩ = 0.101, CI95 = 0.051, 0.164) of variation contributing to Alzheimer’s disease risk (see Table 2), whereas, in Reduced Model 2, AP for the PRS.no.APOE accounted for 2.4% (σ2Aᴩ-APOE = 0.024, CI95 = 0.004, 0.065) (see Table 2).