The expression of the CerS1 primary band (∼40 kDa) was lower in Huntington’s disease caudate compared to controls when adjusted for both β-actin (−57.60%, P = 0.0025) (Fig. 5B) and GAPDH (−23.34%, P = 0.0098) (Fig. 5D). Here, CERS1 is linked to juvenile Huntington disease.