ADAMTS12 and stroke disorder: At the protein-coding gene level, ADAMTS12 genetic variation is associated with pediatric stroke [74], GLRX2 is implicated in neuroprotection during hypoxia and ischemia [75], and ALOX5 is known to be induced by hypoxia [76] and mediates the production of pro-inflammatory leukotrienes, which induce bronchoconstriction and vasoconstriction [58] as well as the generation of lipid peroxidases secondary to lipoxygenase production [77].