When cerebral ischemia occurs, IL-1β and other inflammatory mediators can activate local endothelial cells and leukocytes and induce significant upregulation of the number of adhesion molecules on the cell surface, which leads to massive adhesion between leukocytes and endothelial cells, causing microvascular obstruction and aggravating brain tissue damage [20, 21]. Here, IL1B is linked to brain ischemia.