The study by Saadi Mahdiye et al. [8] found that the elevated sICAM-1 and osteoprotegerin are the independent risk factors for leukoaraiosis, and another meta-analysis found that [24] c-peptide levels cause endothelial function lesions in cerebral small vessel and are one of the main causes of cerebral white matter hyperintensity. This evidence concerns the gene TNFRSF11B and Abnormal cerebral white matter morphology.