The results showed that SEC61A1 (Fig. 5A), ALDH18A1 (Fig. 5B), TP53 (Fig. 5C), PDCD11 (Fig. 5D) and MCM3 (Fig. 5E) were lowly expressed in severe asthma, which was consistent with the results in GSE69683 and GSE27011. The gene discussed is ALDH18A1; the disease is asthma.