Thus, blood-derived memory CD4+ T cells from IBD patients exhibited a skewed pro-inflammatory over anti-inflammatory cytokine balance in response to Notch/STAT3 co-stimulation, which was characterized by reduced expression of IL-10 in CD patients and increased inflammatory IL-17 and IL-17/IFN-γ co-production in CD and UC patients. This evidence concerns the gene STAT3 and inflammatory bowel disease.