Interestingly, a more detailed analysis of DLL4 + STAT3 cytokine-induced IL-10 production by individual Th cell subsets revealed a uniform reduction of IL-10 expression among Th1 (IFN-γ+), Th17 (IL-17+) and Th1/17 (IL-17+/IFN-γ+) cells as compared to HD (Fig. 5b). This evidence concerns the gene IFNG and Huntington disease.