JAK2 and atherosclerosis: Our in vivo results are corroborated by our findings in vitro in BMDM as well as in blood monocyte-derived macrophages of individuals in response to JAK2 inhibition or in subjects carrying the Jak2-activating mutation that together support the predominant role of JAK2 in enhancing cholesterol efflux from macrophages that likely contribute to accelerated atherosclerosis.