Finally, we subjected M-Jak2 KO and WT mice on HCD with TO901317 or vehicle for 3 weeks and found that plaque burden was attenuated in M-Jak2 KO mice exposed to TO901317, showing the critical role of cholesterol efflux that was regulated by JAK2 in determining atherosclerosis progression40,41. This evidence concerns the gene JAK2 and atherosclerosis.