As illustrated in Fig. 2, a signature consisting of FZR1 and USP10 stratified luminal BC patients into groups of different levels of p27 and in the expected pattern (i.e., the high-ubiquitination group having the highest p27 levels and the low-ubiquitination group having the lowest levels), although this pattern was just above the threshold for significance at a cutoff of p = 0.05 (one-way ANOVA p = 0.059, F = 2.85, group DOF = 2, residuals DOF = 626). This evidence concerns the gene FZR1 and breast cancer.