SKP2 and breast cancer: Of the seven of these drugs predicted to have the desired transcriptional perturbation in a luminal BC cell line (MCF7), two have been shown to downregulate SKP2 and stabilize p27 in BC cell lines (sirolimus and vorinostat), and one has been shown to induce G1 arrest in BC cell lines independent of DRD2 (thioridazine)41–43.