HLA-B*58:01 diplotypes (homozygous or heterozygous) were present in 5.9% of the population studied, indicating significantly increased risk of allopurinol-induced severe cutaneous adverse reaction (SCAR), which is manifested by Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS)40. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.