Similarly, in the MB49 mouse model of bladder cancer, BCG-disA-OE was superior to BCG-WT in reducing tumor growth with associated increase in tumor necrosis, and these effects were accompanied by significantly higher recruitment of activated, inflammatory macrophages, IFN-γ-producing CD4 T cells, and reduced accumulation of Treg cells in the tumors. The gene discussed is CD4; the disease is neoplasm.