Among tumor-infiltrating lymphocytes, there were large reductions in total lymphocytes and activated CD8 + T cells (IFN-γ+CD8 cells, CD25+CD69+CD8 cells, and CD69+CD38+CD8 cells) in tumors from treated STING−/− mice compared with WT mice, changes that were less pronounced in untreated or BCG-WT treated STING−/− and WT mice (Fig. S15d–g). The gene discussed is STING1; the disease is neoplasm.