Monoallelic pathogenic variants in MYH3 cause distal arthrogryposis (DA) syndromes, including arthrogryposis, distal, type 2A (DA2A, Freeman–Sheldon syndrome, MIM#193700) and arthrogryposis, distal, type 2B3 (DA2B3, Sheldon–Hall syndrome, MIM#618436)3. The gene discussed is MYH3; the disease is Freeman-Sheldon syndrome.