Ikaros (IKZF1) and Aiolos (IKZF3) are transcription factors with crucial roles in immune cell development and homeostasis.5IKZF1 and IKZF3 mRNA are overexpressed in the peripheral blood mononuclear cells of patients with SLE,6 contributing to lupus disease pathology.7 Polymorphisms in both IKZF1 and IKZF3 are associated with a risk of developing SLE.8–10. Here, IKZF3 is linked to systemic lupus erythematosus.