Taken together, we present convergent and consistent lines of evidence suggesting that rs6781790 may confer PD risk by regulating the expression of AMT and DALRD3. Therefore, perturbation of the expression of PD risk genes (e.g., AMT and DALRD3) may underlie the identified functional PD risk variants and have pivotal roles in its pathogenesis. This evidence concerns the gene DALRD3 and Parkinson disease.