With this aid, large-scale biomarker profiling in gynecologic tumors based on 441 PEA targets showed a panel of 27-protein biomarkers to distinguish benign tumors and high-grade ovarian cancer with a sensitivity of 0.88 and specificity of 0.92 (AUC = 0.92), and its diagnostic performance was significantly better than conventional CA125 and human epididymis protein 4 (HE4) biomarkers [56]. This evidence concerns the gene WFDC2 and ovarian cancer.