These reports together with our results support that ICMT, OGDH, TKT, ZMPSTE24, RPS6KA1, CACNA1B, and MAPK8IP3, as well as pathways for biosynthesis of antibiotics, terpenoid backbone biosynthesis, and MAPK signaling pathway may play important roles in osimertinib resistance in NSCLC. Here, RPS6KA1 is linked to non-small cell lung carcinoma.