KEGG analysis clearly revealed that these 2092 genes were mainly enriched in extracellular matrix-receptor interaction, cardiomyopathy, and vascular smooth muscle contraction, implying that vascular remodeling and increased vasocontraction might exist in db/db mice, in which TGF-β signaling pathway might also played a role (Fig. 5C). This evidence concerns the gene TGFB1 and cardiomyopathy.