SPPL3 and acute myeloid leukemia: Of note, (neo)lacto-series GSL synthesis is initiatedby B3GNT5 which recently has been found to be stronglyregulated by the protease SPPL3 at the post-translational level pointingtoward an important role of (neo)lacto-series GSLs in the inhibitionof immune recognition.39 Accordingly, onemay speculate about the potential immunosuppressive roles of (neo)lacto-seriesGSLs in AML.