Our data reveal TFs GATA2, GATA1, and RUNX1 as candidateinducers of the expression of gangliosides and sialylation via regulationof the GTs ST3GAL2 and ST8SIA1.In conclusion, we show that GSL glycan expression levels are associatedwith hematopoietic AML classifications and TF and GT gene expression.Further research is needed to dissect the regulation of GSL expressionand its role in hematopoiesis and associated malignancies. Here, GATA1 is linked to acute myeloid leukemia.