Among them, 11 switch genes (i.e., CENPN, LRP8, DSCC1, CTPS, RCOR2, GINS4, TUBA1C, PRAME, SLC7A11, CDCA7, GSDMC) appeared to be an unfavourable prognostic gene (Fig 2), suggesting that their higher expression could be associated with poorer BC patients’ overall survival (OS). Here, GSDMC is linked to breast cancer.