Among them, 11 switch genes (i.e., CENPN, LRP8, DSCC1, CTPS, RCOR2, GINS4, TUBA1C, PRAME, SLC7A11, CDCA7, GSDMC) appeared to be an unfavourable prognostic gene (Fig 2), suggesting that their higher expression could be associated with poorer BC patients’ overall survival (OS). This evidence concerns the gene TUBA1C and breast cancer.