ITGB3 and neoplasm: In addition, downregulated proteins were assigned to multiple genes associated with pathways for carcinogenesis (Cryl1, Usp11, Gnao1, Gnao1, Grhpr, Ppp1r14a, Hopx) tumor suppression (Usp11, Gas1, Cbr1), cell survival (Bcl-2), and reduced structural integrity and cell adhesion (Itgb3, Itga1, Itga7, Armc1, Usp11, Dmd, Mapre3).