Prior studies have identified NADPH oxidase 4 (NOX4), mouse double minute 4 homolog (MDM4), and the transcription factor myogenic differentiation 1 (MyoD) as factors that contributed to myofibroblast senescence and apoptosis resistance during persistent lung fibrosis in aged mice (11, 13–15). Here, MYOD1 is linked to pulmonary fibrosis.