While there is strong evidence supporting the crucial role of NLRP3 inflammasome activation and IL-1β secretion in cardiovascular lesion development during human KD and in murine models of KD vasculitis (7, 10, 41, 42), and ER stress is an established inducer of NLRP3 inflammasome activity (33, 43), the role of ER stress during KD vasculitis has not previously been investigated to our knowledge. Here, NLRP3 is linked to vasculitis.