After stimulation with LCWE, BMDMs from LysΜCre+Ern1Δ/Δ mice showed reduced mRNA levels of Il1b compared with BMDMs generated from Ern1fl/fl controls, indicating that inhibition of the IRE1 pathway may lead to reduced NLRP3 activation, consistent with previous findings in other types of cardiovascular diseases (27, 46). Here, ERN1 is linked to cardiovascular disorder.