To further analyze the role of IRE1 in myeloid cells during LCWE-induced KD vasculitis, we generated mice with myeloid cell–specific IRE1 deficiency by crossing mice harboring a Cre recombinase under the control of the endogenous Lyz2 promoter (LysMCre) with Ern1fl/fl mice (40). The gene discussed is ERN1; the disease is vasculitis.