ERBB2 and neoplasm: While these anaphylotoxins and their receptors can also impact adaptive immunity such as DC, B cell, and T cell function (24, 25, 62), our studies of immunocompetent HER2 transgenic mice did not reveal drastic changes in lymphocyte infiltration (Supplemental Figure 14) or HER2-specific T cell adaptive responses with T+P therapy, despite an increase in complement activation, tumor cell death, and improved survival in these mice (Figure 1E and Supplemental Figure 6E).