The compounds are involved in pathways including pathways related to angiogenesis, apoptosis, autophagy, cancer, neurological disease, cell cycle progression, cytoskeletal signalling, DNA damage, endocrinology and hormones, epigenetics, GPCRs and G proteins, immunology and inflammation, metabolic disease, metabolism, the metabolism system, microbiology, neuronal signalling, NF-κB, PI3K/Akt/mTOR, proteases, stem cells and Wnt, transmembrane transporters, and so on (Fig. 1, A). The gene discussed is MTOR; the disease is Other metabolic disease.