AURKA, abnormally expressed in multiple cancers, is closely related to the occurrence and development of tumors, such as lung cancer [14], head and neck squamous cell carcinoma [15], and CRC [16], etc. AURKA regulates Wnt and Ras-MAPK signaling pathways, thereupon promoting CRC progression [17]. This evidence concerns the gene AURKA and head and neck squamous cell carcinoma.