In further bioinformatics analysis of METTL5 in UCEC patients using Pan-Cancer and the target gene system, we found that METTL5 was negatively correlated with gene silencing, mRNA binding, olfactory receptor activity, antigen processing and presentation, cytosolic DNA sensing in GO, antigen processing and presentation, cytosolic DNA sensing pathways, olfactory transduction, and RIG-1-like and Toll-like receptor signaling pathways in KEGG. This evidence concerns the gene METTL5 and cancer.