CTNNB1 and neoplasm: This finding was also reported in previous retrospective studies,19,20 although the predictive value of tumor size was not confirmed by Colombo et al.13 It has been reported that the S45F mutation is associated with a higher risk of recurrence in surgically treated DTF patients, suggesting a more aggressive behavior.26,28 The influence of CTNNB1 mutations on change in treatment strategy was not investigated previously.