CTNNB1 and neoplasm: Tumor localization, age at diagnosis, CTNNB1 mutation status, and tumor size are most frequently reported as potential clinicopathological factors associated with recurrence, tumor behavior, or change in treatment strategy in DTF patients.13,17,19–21,24–27 In this study, a larger tumor size at baseline (≥5 cm) was associated with a higher risk to start active treatment in the univariable analysis.