SDC1 and Miyoshi myopathy: Importantly, we also found a negative correlation between HRP2 and H3K27me3 levels in CD138+ cells isolated from t(4;14)-positive patients with MM, in which patients with a CR after 8 cycles of a bortezomib-based treatment regimen had higher HRP2 expression and lower H3K27me3 expression, and vice versa for patients with RR (Figure 5C and Supplemental Figure 5B).