The t(4;14) (p16;q32) translocation confers high expression of fibroblast growth factor receptor 3 (FGFR3) and nuclear SET domain–containing 2 (NSD2, also known as WHSC1/MMSET) genes and is one of the most common translocations in patients with MM, accounting for 15% to 20% of all chromosomal abnormalities (5). Here, NSD2 is linked to Miyoshi myopathy.