HDGFL2 and neoplasm: When we evaluated the in vivo effects of HRP2 depletion on resistance to bortezomib treatment, we found that HRP2 depletion did not affect tumor growth in a xenograft model, but rather induced tolerance to bortezomib treatment compared with the nontarget controls (Figure 3, A and B) and significantly impaired the survival rate of mice (Figure 3C).