FN1 and malignant colon neoplasm: This and another early study showing Fn’s immunosuppressive and proapoptotic effects on lymphocytes and myeloid cells (87) foreshadow later work on Fn’s myeloid cell immunomodulatory roles in the ApcMin/+ model (88), Fap2’s proinflammatory effects on myeloid cells cocultured with colon cancer cells (89), Fap2’s interactions with TIGIT (81), and Fn’s Th17-enhancing functions in the colon (90).