GSK3B and chronic kidney disease: To this end, GSK3β has been shown to play a key role in regulating injury of various kidney cells, like podocytes (21), and is centrally involved in pathogenesis of diverse kidney diseases, such as glomerular disease (23), acute kidney injury (AKI) (24, 25), diabetic nephropathy (26), and chronic kidney disease (CKD) (27, 28).