Moreover, as determined by gene set enrichment analysis (GSEA) (Figure 1B), the expert-curated kidney-aging-related gene set RODWELL_AGING_KIDNEY_ UP exhibited significant enrichment in high expression of GSK3β as compared with low expression of GSK3β in normal and diseased glomeruli based on the Ju CKD Glom data set (30). This evidence concerns the gene GSK3B and chronic kidney disease.