MGP and chronic kidney disease: However, Sevinc’s study showed that in stage 2–5 CKD patients who did not require dialysis treatment, there was no correlation between MGP and vascular calcification as expressed with carotid intima-media thickness, whereas the level of Fetuin-A (a major inhibitor of calcium and phosphate precipitation) began to decline from the early stages of CKD, and Fetuin-A levels were negatively correlated to vascular calcification [23].