In addition, many new signaling molecules that regulate kidney fibrosis have been found, such as protective nature of endothelial glucocorticoid receptors, endothelial SIRT3, endothelial FGFR1 against renal fibrosis and, podocyte–glucocorticoid receptor signaling in protecting diabetic nephropathy [6–9]. The gene discussed is SIRT3; the disease is diabetic kidney disease.