To understand the mechanism of TGF‐β activation in tendons during tendinopathy, we first stained Achilles tendon sections with integrin αvβ6 antibody since the αvβ6 integrins are known to mediate cell‐induced conformational change of TGF‐β latent complex to release active TGF‐β. This evidence concerns the gene TGFB1 and disease of the tendon.