TGFB1 and cranioectodermal dysplasia: In CED, TGF‐β1 is constitutively active upon secretion due to a point mutation in the TGFB1 gene.[23, 26] Previously, we generated a CED mouse model with a CED‐derived TGFB1 mutation (H222D), in which active TGF‐β1 is overexpressed in Col1‐enriched tissues,[24a–c] such as tendons (Figure 3A).