Considering that PD patients are usually characterized by low serum 25(OH)D,12 data in the different study groups presented low heterogeneity and VDR and CYP24A1 are similarly expressed in brains of PD patients and controls, a noteworthy question raised by our findings is how CYP27B1 can prevent neurotoxic alterations and promote α‐Synuclein uptake by astrocytes? Here, CYP27B1 is linked to Parkinson disease.