Fibronectin type III domain‐containing 5 (FNDC5) is a type I transmembrane glycoprotein that can be proteolytically processed at the carboxy‐terminal to release irisin, an exercise‐responsive myokine conferring cardioprotection in response to different pathological stimulations, such as cardiac remodeling, ischemia/reperfusion injury, and diabetic cardiomyopathy (Bostrom et al., 2012; Zhang et al., 2020). This evidence concerns the gene FNDC5 and diabetic cardiomyopathy.