The members of integrin family, especially ITGAV and ITGB5, are potential receptors of irisin in osteocytes and fat cells, and simultaneous knockdown of ITGAV and ITGB5 also blocked FNDC5‐mediated protective effects against diabetic cardiomyopathy (Kim et al., 2019; Lin et al., 2021). Here, FNDC5 is linked to diabetic cardiomyopathy.