STK11 and neoplasm: This gene encodes for liver kinase B1 (LKB1), a protein kinase involved in cellular energy homeostasis [28]. In cancer cells with oncogenic driver mutations (e.g. KRAS, EGFR, or ALK), LKB1 deficiency has been observed to accelerate tumor development by inducing metabolic reprogramming of glucose, lipid, glutamine, and serine [29].