Unlike GRP78, the upregulation of CHOP could be found only in ADTKD-UMOD cases, not in other CIN patients, and there were also definite colocalization of CHOP with uromodulin, suggesting that the activation of CHOP is specific in the pathogenesis of ADTKD-UMOD. Here, DDIT3 is linked to cervical squamous intraepithelial neoplasia.