In order to further clarify the substances in the expanded ER, specific immunofluorescent staining of uromodulin was performed in the paraffin-embedded renal sections of two probands (the renal biopsy paraffin sample of case 3 could not be obtained), one healthy donor kidney (HNK) and 23 sporadic chronic interstitial nephritis (CIN) patients. This evidence concerns the gene UMOD and cervical squamous intraepithelial neoplasia.